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You are using an out of date browser. Many people boast the benefits of vitamin B-3 for treating depression. Sleep, REM / drug effects. Baltimore, MD: Williams & Wilkins, 1999. This is not a problem if you're taking one tablet a day, but for anxiety the daily dosage of niacinamide generally ranges from 1000 to 3000mg. More high-quality studies are needed before using niacinamide for these conditions. Niacinamide is one form of vitamin B3 (niacin) that plays an important role in energy metabolism and cell health. Its been suggested that niacinamide protects and preserves the beta cells, thereby preventing or delaying the onset of type 1 diabetes in at-risk individuals (21, 22, 23). This article discusses potential uses for niacinamide, possible side effects, precautions, niacinamide dosage, known interactions, and other essential facts regarding niacinamide supplements. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. The evaluation and management of reactive hypoglycemia and food allergy are discussed in chapters 6 and 7, respectively. Depending on your unique needs, health conditions, or other medications or products used, you may need more or less niacinamide. There seems to be some potential for niacin to help improve sleep quality, but theres a lack of research on this topic. Most likely, getting extra niacin is only beneficial for someone not getting enough in their diet. Pregnancy and breastfeeding: Niacinamide is generally acceptable in pregnant or breastfeeding people. If you're experiencing pellagra symptoms, please contact your healthcare provider for further guidance. 2004;65(3):1099-104. It has many health benefits, along with several side effects if you take large doses, Niacin, or vitamin B3, is an essential nutrient, which aids your metabolism and nervous system and which you must obtain through your diet. Connell NJ, Grevendonk L, Fealy CE, et al. Pharmacological doses may induce hypothermia and may cause plasma melatonin levels to remain elevated into the daytime hours.33. The book reviews the use of diet, nutritional supplements, and other natural substances for the prevention and treatment of more than 400 health conditions. It is also a more active metabolic substrate that is converted into an enzyme called "Co-Enzyme A" (CoA). There have been many scientific studies that show that meditation helps with depression. 2002 Jul;147(1):20-31. Kamal M, Abbasy AJ, Muslemani AA, Bener A. Excess oral intake of niacinamide can lead to gastrointestinal issues, such as nausea, vomiting, and diarrhea, per the NIH, as well as skin redness, says Nazarian . Int J Vitam Nutr Res. Acne. Medicine. Gale EA, Bingley PJ, Emmett CL, Collier T; European Nicotinamide Diabetes Intervention Trial (ENDIT) Group. Essentially, tryptophan converts to niacin in the body. View abstract. Vitamin B6 deficiency has been linked to irritability, emotional disturbances, confusion and disturbed sleep among other effects. Cancer. Wyatt is still sweet, happy, and healthy, and has not required antipsychotics for psychotic or violent behavior since we discovered niacin. Navarrete-Sols J, Castanedo-Czares JP, Torres-lvarez B, et al. I will also only be able to sleep 4-5 hours. Ulcers: People with stomach ulcers may need to avoid using niacinamide as it may worsen ulcers. Dietary supplements are not regulated in the United States, meaning the Food and Drug Administration (FDA) does not approve them for safety and effectiveness before products are marketed. 2005;103(11):2287-97. Some people claim that supplementing niacin (vitamin B3), or focusing more on foods high in niacin, has cured or improved their insomnia. 2005-2023 Healthline Media a Red Ventures Company. Your body can also make vitamin B3 from tryptophan, an amino acid present in most protein foods. Cookies collect information about your preferences and your devices and are used to make the site work as you expect it to, to understand how you interact with the site, and to show advertisements that are targeted to your interests. The umbrella vitamin B3 includes nicotinic acid and nicotinamide. 14 to 18 years, male: 16 mg NE. Biol Psychiatry 1977;12:139-143.20Freyre AV, Flichman JC. View abstract. One study found that elderly people with delayed sleep phase syndrome (i.e., they could not fall asleep until 5 a.m.) who responded to 1-2 mg of melatonin at night, could successfully discontinue the treatment after 8 weeks without experiencing a return of their abnormal sleep patterns. Vitamin B3, in the form of nicotinic acid or niacinamide, is available as a supplement either by itself or alongside other vitamins and minerals in doses ranging from 14 to 1,000 mg per serving. For oral dosage forms (extended-release capsules, oral solution, or regular tablets): Adults500 to 2000 milligrams (mg) one to three times a day. 1 to 3 years: 10 mg NE. Human tumor blood flow is enhanced by nicotinamide and carbogen breathing. . However, the conversion of tryptophan to vitamin B3 is inefficient, as it takes 60 mg of tryptophan to make just 1 mg of vitamin B3 (1). How to improve sleep quality naturally. Med Hypotheses 1999;53:350-60. While there are no studies examining magnesium as a treatment for insomnia, this mineral has been reported to improve sleep efficiency in patients with insomnia associated with restless legs syndrome or periodic limb movements in sleep.22, Vitamin B12: In case reports, 5 patients with chronic (> 18 months) disorders of their sleep-wake cycle improved after supplementation with 1,500-3,000 g/day of vitamin B12. The ideas, opinions, commentaries and viewpoints expressed on this website do not necessarily reflect those of its publisher. Taking niacinamide along with medications that also slow blood clotting might increase the risk of bruising and bleeding. Ketteler M, Wiecek A, Rosenkranz AR, et al. He also takes Methylphenidate (generic Ritalin) and Clonidine for sleep. Biomolecules. This makes niacinamide a popular alternative to oral or topical antibiotics for treating acne or rosacea (7, 8). 2013 Sep 19;122(12):2104-13. Necrosis predicts benefit from hypoxia-modifying therapy in patients with high risk bladder cancer enrolled in a phase III randomised trial. Owing to its role in keeping your cells healthy, oral supplements of niacinamide have been shown to enhance DNA repair in UV damaged skin in humans (9, 10). Itching. There are eight B vitamins that all play vital roles in your body. Jonas WB, Rapoza CP, Blair WF. 2020;33(4):e13534. View abstract. Upset stomach or throwing up. By Ayda Ersoy The Diet Doc | Wednesday, February 13, 2019, 12:05 a.m. Share this story. Vitamin E and nicotinamide have similar effects in maintaining residual beta cell function in recent onset insulin-dependent diabetes. StatPearls Publishing; 2022. 2013 Sep;24(5):995-9. Niacinamide is generally considered safe in doses of less than 35 milligrams (mg) per day. Your body can convert tryptophan from food into niacinamide as needed, and it may make niacinamide from niacin to an extent when there's enough of it. Kidney Int. CoA plays a critical role in the metabolism and . Overall, niacinamide can help build proteins in the skin and lock in moisture to prevent environmental damage. View abstract. View abstract. Alt Med Rev 2002;7:525-9. View abstract. Exposure to ultraviolet (UV) radiation, either from the sun or tanning beds, damages the DNA of your cells over time and is strongly correlated with melanoma. Huber R, Wong A. Nicotinamide: an update and review of safety & differences from niacin. Int J Dermatol. Effect of standard nicotinamide in the prevention of type 1 diabetes in first degree relatives of persons with type 1 diabetes. A study of Dutch university students found (2): In other words, there was a small but significant correlation between niacin intake and sleep quality. The Food and Nutrition Board defines 1 Niacin Equivalent (NE) as 1 mg niacin or 60 mg of tryptophan (which can be converted to niacin in the body). 5. For a better experience, please enable JavaScript in your browser before proceeding. Insomnia and cows milk allergy in infants. Thus, in some individuals a significant amount of caffeine will be present in the blood at bedtime, even if caffeine is consumed only in the morning. 10 niacin benefits and its side effects. Melatonin and sleep in the elderly. View abstract. Jorgensen J. Pellagra probably due to pyrazinamide: development during combined chemotherapy of tuberculosis. Speak with your healthcare provider to see if they think niacinamide can help. Go have fun. 2009;2:45-60. doi:10.4137/ijtr.s2129. Serums may contain vitamin B5, vitamin C, licorice extract, and glucosamine. What Happens If I Take Too Much Niacinamide? 2019;2(4):e192224. Gale EA. Even if niacin does help, it doesnt look like it has a large effect compared to more established treatment methods. View abstract. My dermatologist said to take 500 milligrams of niacinamide, twice a day, because studies show that this form of Vitamin B3 cuts down the risk of non-melanoma skin cancers, such as the squamous cell carcinomas to which I am prone. Hepatic toxicity from large doses of vitamin B3 (nicotinamide). I may try it again. Interactions between primidone, carbamazepine, and nicotinamide. Your healthcare provider may recommend that you take a niacinamide supplement for any of the reasons discussed in the previous section. I'll try to find it. Another B3 feature is its ability to greatly reduce anxiety and depression. No matter the reason for taking niacinamide, it's essential to know and understand any common or severe side effects you may or may not experience. Niacinamide / pharmacology*. 2019;17(8):e05775. View abstract. Talk with your healthcare provider when deciding how much niacinamide to take daily. Taking niacinamide by mouth might help slow the progression of type 1 diabetes . 2005;68(6):2911-2. When applied to the skin: Niacinamide is possibly safe. Taking between 100 and 500 milligrams about 20 minutes before bedtime usually works best. Cells. Niacinamide (nicotinamide) is a form of vitamin B3 (niacin) and is used to prevent and treat niacin deficiency (pellagra). Psychosomatics 1970;11:500-502.21Seelig MS. Diarrhea . The Blu Atlas eye stick is living proof that not all eye creams are created equally, so if you're looking for a naturally derived product to minimize . Accelerated radiotherapy, carbogen, and nicotinamide in glioblastoma multiforme: report of European Organization for Research and Treatment of Cancer trial 22933. Nutrients. Pediatrics 1985;76:880-884.4Rowe AH. Fabbrocini G, Cantelli M, Monfrecola G. Topical nicotinamide for seborrheic dermatitis: an open randomized study. It's chemical structure is C6/H12/06. Neuropharmacology 1979;18:1025-1027.17Hartmann E, Lindsley JG, Spinweber C. Chronic insomnia: effects of tryptophan, flurazepam, secobarbital, and placebo. Diabetes Metab Res Rev 1999;15:181-5. Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome: an open pilot study. View abstract. Biological properties of vitamins of the B-complex, part 1: vitamins B1, B2, B3, and B5. Diabetologia 1995;38:848-52. 2020;9(12):2660. While there is such a thing as bad cholesterol, good cholesterol is actually important for heart health. Other Benefits of Vitamin B3 Niacinamide Anxiety, Mood & Sleep. 2023 Dotdash Media, Inc. All rights reserved, Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. OK, no worries, not criticizing what you said. Niacinamide supplements may be necessary to treat certain skin conditions. Some supplements that contain vitamin B3 only list niacin, but most supplements specify the form of niacin as either nicotinic acid or niacinamide. Interesting! For example, NAM by itself inhibits poly (ADP-ribose) polymerases (PARPs), which protect genome integrity. Niacinamide is generally well-tolerated in appropriate doses, largely because excess amounts are excreted with your urine ().The tolerable upper limit of vitamin B3 is 35 mg per day. View abstract. JAMA Netw Open. 2015;30(1). Niacinamide helps in sleep enhancement as evidenced in a 3-week study of six subjects with normal sleep patterns and two with insomnia using electroencephalograms, electromyograms, and electrooculograms to evaluate sleep patterns at baseline and after niacinamide treatment. J Pediatr Endocrinol Metab 1996;9:375-9. 2006;39(4):333-40. Stress factors gradually reduce and the mind and body learn to sleep on a regular schedule. 2012;11(12):1428-33. Carbogen and nicotinamide combined with unconventional radiotherapy in glioblastoma multiforme: a new modality treatment. However, possible adverse effects and their mechanisms are poorly understood. The dictionary definition is a condition of body and . Swash M, Roberts AH. How does niacin help sleep? My sleep is Advanced Sleep Phase so I go to sleep naturally ar7-8 pm, awake 10-11 unable to get back to sleep till 3-4 am. Vitamin B6, or pyroxidine, is a water-soluble vitamin that is responsible for many processes in the human body. Niacin or plain old niacin, niacinamide, a no flush form that works just right for all mental and emotional issues but does not work for cholesterol issues. 2018;97(41):e12731. ~3.5 grams (g) per day) for up to 12 months, have been used in different studies. Let's say you do 2000mg a day--that's 4 tablets, each containing 160mg of . I had been taking niacinamide for quite awhile which didn't seem to affect me at all, good or bad . Applies to the following strengths: 100 mg; 500 mg. CONTRAINDICATIONS: Hypersensitivity to the active ingredient L-Tryptophan has also been reported to be effective for insomnia in chronic alcoholics.15, Some studies have found that L-tryptophan is not beneficial for insomnia. Theres not much research on niacin and insomnia. Modern Nutrition in Health and Disease. Know what else is in your supplements before taking them. If you can find the source that would be great, and if not, then no biggie. Pharmacol Biochem Behav 1982;17:65-71. They will be able to help diagnose and treat this condition. Available for Android and iOS devices. B3 megadose for starch intolerance, IBS, and more. He experienced considerable improvement, and at his last follow-up visit 3 years later, was still sleeping well on the same regimen. Saul: Niacin is the best therapy in existence for normalizing blood lipids. But there's a big difference between the two forms. Centre for Clinical Practice at NICE (UK). View abstract. View abstract. 3. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Clin Pharmacol Ther 1983;33:770-775.10Tiffin P, Ashton H, Marsh R, Kamali F. Pharmacokinetic and pharmacodynamic responses to caffeine in poor and normal sleepers. Med Tribune 1984(August 15):2.15Anonymous. Consult WARNINGS section for additional precautions. Inflammatory acne management with a novel prescription dietary supplement. View abstract. Be very careful in the use of therapeutic doses of niacinamide in patients who have, or are at risk of developing, liver disease (such as chronic alcoholics). The combination is usually well-tolerated, with gastrointestinal side . One group of researchers essentially tried to do what Im trying to do here. Skin Res Technol. One study in which L-tryptophan was not effective lasted only 2 days,16 but it may take up to 2 weeks before a beneficial effect is seen.17, In a study of patients with severe insomnia, those who reported clear awakenings 3-6 times per night showed a good response to L-tryptophan, whereas there was no improvement in patients who experienced clear awakenings 1-2 times during the night, or in those who reported dozing on and off throughout the night, twilight sleep, and a blurring between sleep and wakefulness.18. Severe side effects of niacinamide include: Be sure to talk to your healthcare provider if you experience side effects from taking niacinamide supplements. Hardman JG, Limbird LL, Molinoff PB, eds. J Nutr 2021;151(10):2917-2931. For example, niacinamide doesn't reduce cholesterol levels like niacin. I take 1,000 mg an hour before I go to sleep, and if I'm having an especially hard night and wake up at 2am, I take another 1,000mg along with my usual kava kava, passion flower, etc. We comply with the HONcode standard for trustworthy health information. While niacinamide is generally well tolerated, administration of large doses has occasionally resulted in clinically significant elevations of aminotransferases (liver enzymes) and, rarely, chemical hepatitis (chapter 15). And then there's . Kozan A, Guner RY, Akyol M. A retrospective assessment and comparison of the effectiveness of benzoyl peroxide; the combination of topical niacinamide, gallic acid, and lauric acid; and the combination of benzoyl peroxide and erythromycin in acne vulgaris. Relative hypoglycemia as a cause of neuro-psychiatric illness. Cervantes J, Eber AE, Perper M, Nascimento VM, Nouri K, Keri JE. Type 1 diabetes is a condition in which your body attacks and destroys the insulin-producing beta cells of the pancreas. 2000;43(11):1337-1345. doi:10.1007/s001250051536. Although they're both different forms of vitamin B3, niacinamide and nicotinic acid ("niacin") have different chemical structures and work differently in your body. Find your people. Accelerated radiotherapy with carbogen and nicotinamide for laryngeal cancer: results of a phase III randomized trial. 2006;71(3):320-33. 2005 - 2023 WebMD LLC. The psychiatrist encouraged the patient to do so but wanted the patient to contact him if he were to experience withdrawal symptoms such as recurrent anxiety, insomnia and irritability. 2011;164(6):1188-1200. doi:10.1111/j.1365-2133.2010.10163.x, Chen AC, Martin AJ, Choy B, et al. Effects of megavitamin therapy on children with attention deficit disorders. Vitamin B3 (Niacin) Therapy as Used by Abram Hoffer, M.D. 4 to 8 years: 15 mg NE. The use of niacinamide and solanaceae (nightshade) elimination in the treatment of osteoarthritis. This is the amount least likely to cause flushing, redness, itching and tingling of your skin, a known side effect of nicotinic acid but not niacinamide (1, 29). It may offer benefits related to skin care and skin cancer, as well as chronic kidney disease and type 1 diabetes. Lampeter EF, Klinghammer A, Scherbaum WA, et al. The correct dosage for Cholest, Niacinamide B3 and NAC are on the labels. Niacinamide's anti-inflammatory effects are thought to reduce the redness and inflammation caused by acne. J Clin Psychiatry 2000;61:373-377.32Garfinkel D, Zisapel N, Wainstein J, Laudon M. Facilitation of benzodiazepine discontinuation by melatonin: a new clinical approach. Fukuwatari T, Shibata K. Effect of nicotinamide administration on the tryptophan-nicotinamide pathway in humans. A randomized, double-blind, placebo-controlled crossover study of the effect of exogenous melatonin on delayed sleep phase syndrome. Taking niacinamide by mouth seems to improve, Brain tumor. Melatonin treatment for age-related insomnia. Some symptoms may directly worsen sleep quality and lead to insomnia. Niacinamide is found in many vitamin B complex supplements with other B vitamins. For someone who already does get a lot of vitamin B3 from food, a supplement can have an adverse effect. Safety of high-dose nicotinamide: a review. If you have questions about side effects, call your doctor. But why? Oral (by mouth) niacinamide (nicotinamide) supplements have been studied for several conditions, including: Topical (on the skin) niacinamide has been studied for use in: It's important to note that niacinamide differs from niacin (also known as nicotinic acid). Regular flushing niacin makes me initially very sleepy but I will wake up feeling like I've barely slept at all, and feel terrible for the rest of the day. Copyright 2023 Holistic Primary Care. J Am Coll Nutr 1994;13:429-446.22Hornyak M, Voderholzer U, Hohagen F, et al. Eur J Cancer. Dosage: How Much Niacinamide Should I Take? Multivitamins may also contain niacinamide, so you'll want to take care when taking supplements together, so you don't get too much. Niacin interferes with glucose metabolism and can result in hyperglycemia. 2020;24(6):642-643. doi:10.1177/1203475420936649, Hruba M, Siatka T, Nejmanov I, et al. Olmos PR, Hodgson MI, Maiz A, et al. Niacinamide supplements, including oral (by mouth) capsules and topical (skin) serums, often contain other ingredients. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. View abstract. Effect of scheduled antimicrobial and nicotinamide treatment on linear growth in children in rural Tanzania: A factorial randomized, double-blind, placebo-controlled trial. It is taken in combination with 1mg Melatonin tablets ( 1 per night) and 1/4 teaspoon powdered ( or pearlized) Oleamide. A multi-centre randomized trial of two different doses of nicotinamide in patients with recent-onset type 1 diabetes (the IMDIAB VI). Arch Intern Med 2004;164:697-705. Despite its favorable safety profile and affordability, the integration of . Caffeine: It is well known that some people experience insomnia when they consume caffeine,6,7 particularly when they have it in the evening. How's it working for you? I said "supposedly" because 1) that's what that source said, and 2) I'm not sure where I read said source. The role of nicotinamide in cancer chemoprevention and therapy. J Orthomol Med. Lancet. Tryptophan in foods may eventually convert to niacinamide in the body through different biochemical pathways. While regular sized doses of niacin arent likely to have much of a negative effect, it varies by person. View abstract. Radiother Oncol. It also includes 61 chapters on vitamins, minerals, amino acids, and other compounds, including biochemical effects, clinical indications, interactions, preparations, and dosage and administration. Here are. Magnesium: Insomnia is one of the symptoms of magnesium deficiency.20 The typical Western diet contains less than the Recommended Dietary Allowance for magnesium. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history. Cabrera-Rode E, Molina G, Arranz C, Vera M, et al. Southern California. Niacinamide's therapeutic effects are likely not related to it acting as a ligand for the benzodiazepine receptor, even though it acts centrally and might have a weak binding affinity for the benzodiazepine receptor. Niacinamide has also been studied for its use in: Further high-quality studies are needed before recommendations can be made. Diabetes Metab Res Rev 1999;15:181-5. View abstract. Its also commonly included in many facial moisturizers and acne or rosacea treatment products. J Cutan Med Surg. A 68-year-old man came to my office with a life-long history of insomnia. View abstract. J Am Geriatr Soc 1996;44(9):S1.36Leathwood PD, Chauffard F. Aqueous extract of valerian reduces latency to fall asleep in man. Relieves insomnia; Helps with bipolar disorder Studies on meditation and depression. Br J Dermatol. It is also the best therapy for ADHD, obsessive-compulsive disorder, anxiety, and bipolar disorder. But despite a relatively strong safety profile, its best to consult with your healthcare provider if you choose to supplement with nicotinamide. View abstract. The effects of nicotinamide upon sleep in humans. View abstract. Kidney Int. This information may not fit your specific health circumstances. The most common side effects of niacin are headaches, dizziness and low blood pressure. Eating a variety of whole foods can help you get most of the necessary vitamins and minerals. When Pantothenic Acid enters our bodies, it forms a substance called Pantethine. Rash, stomach upset, elevated liver enzymes (rare side effects, has happened at a dose of more than 3 grams (g) per day), and symptoms of thrombocytopenia (low platelet counts in people with renal disease on dialysis) have been reported. All Rights Reserved. While it can be taken an hour before bedtime to promote restfulness, many users note that the best effects occur when Inositol is taken daily over extended periods of time. In this article we will bring together all the quotes we can find about the incredible properties of Niacinamide that Ray Peat has touched on over the years. 1. 5,898. Niacinamide and nicotinic acid (aka "niacin") are common forms of vitamin B3 in supplements. In people undergoing dialysis through the vein, the most common side effects of niacinamide (500 to 1,500 milligrams (mg) per day for several months) were diarrhea and low platelet counts (thrombocytopenia). Papa CM. Int J Dermatol 1983;22:44-5. Could This Version of Vitamin B-3 Actually Slow Aging? Background: In multiple chronic clinical studies, topical niacinamide (vitamin B3) has been observed to be well tolerated by skin and to provide a broad array of improvements in the appearance of aging facial skin (eg, reduction in the appearance of hyperpigmentated spots and red blotchiness). This will ensure you know the correct dosage for your health needs and goals. 2019;86(4):451-458. You can find out more about our use, change your default settings, and withdraw your consent at any time with effect for the future by visiting Cookies Settings, which can also be found in the footer of the site. Improved recurrence-free survival with ARCON for anemic patients with laryngeal cancer. Niacinamide: Administration of 3 g/day of niacinamide to 2 women with moderate-to-severe insomnia and to 6 individuals with normal sleep patterns resulted in a significant increase in rapid-eye-movement (REM) sleep in all cases. Buy 21st Century Niacinamide 500 mg Prolonged Release Tablets, 110-Count on Amazon.com FREE SHIPPING on qualified orders . Hakozaki T, Minwalla L, Zhuang J, et al. First time I've slept more than 7 hours straight. View abstract. While niacinamide may be safe in higher amounts, side effects may arise (ex., increased bleeding, stomach upset). View abstract . Diabetes 1996;45:1631-4. Melatonin: Melatonin is a hormone secreted by the pineal gland that plays a role in regulating the sleep-wake cycle. View abstract. View abstract. The effect of niacinamide on osteoarthritis: a pilot study. Rottembourg JB, Launay-Vacher V, Massard J. Thrombocytopenia induced by nicotinamide in hemodialysis patients. It might cause side effects such as stomach upset, gas, dizziness, headache, and rash. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). What is niacinamide good for? One gram of L-tryptophan fails to alter the time taken to fall asleep. View abstract. Int J Dermatol 1995;34:434-7. Blackstrap Molasses. As I. the one positive from regular niacin is that it seems to make my normally bloated gut completely shrink and flatten, whereas niacinamide if anything makes my gut stick out even further!! Vitamin B-3 as niacin or niacinamide, in larger than RDA doses, will help induce sleep. Omidian M, Khazanee A, Yaghoobi R, Ghorbani AR, Pazyar N, Beladimousavi SS, Ghadimi M, Mohebbipour A, Feily A. - Ray Peat. You wont find many licensed doctors prescribing niacin supplements for insomnia.